Scientific research is essential to improve the health and well-being of people around the world, and to respond to health emergencies. Since the 1960s many ethical and professional guidance documents have been adopted, typically focusing on individual researchers’ responsibilities to conduct ethical, good quality scientific studies. But to what extent are researchers given the necessary resources for this purpose at their institutions? These CIOMS guidelines review the existing standards and best practices in the field, and offer research institutions detailed and specific guidance on how to implement them.